SuppIndex — The Global Supplement Ingredient Evidence Database

Creatine monohydrate is one of the most well-researched and effective sports nutrition supplements available. It has been shown to increase strength, power output, and lean body mass across hundreds of human clinical trials.

Ashwagandha (Withania somnifera) is a premier adaptogenic herb used for centuries in Ayurvedic medicine. Modern clinical research supports its role in reducing cortisol, improving stress resilience, and supporting hormonal balance.

Vitamin D3 (cholecalciferol) is a fat-soluble secosteroid essential for calcium absorption, bone mineralization, immune regulation, and neuromuscular function. Deficiency is highly prevalent globally.

Magnesium glycinate is a highly bioavailable form of magnesium chelated with glycine. It is favored for sleep support and muscle recovery due to excellent absorption and tolerability.

Apigenin (4',5,7-trihydroxyflavone) is a dietary flavone abundant in chamomile (Matricaria chamomilla), parsley, celery, and thyme. It is best known as a natural sleep aid via GABA-A benzodiazepine-site modulation and has emerged as a CD38 inhibitor that helps preserve cellular NAD+. Popularized by Andrew Huberman as part of a sleep stack, isolated apigenin has strong mechanistic data but no published RCTs in humans — all clinical evidence to date uses chamomile extracts standardized to apigenin.

Berberine is an isoquinoline alkaloid found in goldenseal, barberry, and Oregon grape. It has remarkable clinical evidence for glucose and lipid metabolism — often compared to metformin in head-to-head trials.

Nitrosigine® is a patented complex of bonded arginine silicate stabilized with inositol (ASI). It delivers a uniquely sustained and clinically superior elevation of plasma arginine and silicon levels compared to standard arginine, producing both vascular and cognitive performance benefits within a single 1500mg dose.

Glycerol is a trihydric sugar alcohol that induces cellular hyperhydration by acting as an osmotic agent in body water compartments. It draws and retains fluid in muscle tissue and plasma, producing dramatic muscle fullness, improved thermoregulation, and enhanced endurance performance — particularly in hot environments. Modern high-yield powder forms like GlycerSize™ and HydroMax® deliver 65% glycerol content, solving the clumping issues of older glycerol monostearate products.

Beetroot Extract provides concentrated dietary nitrate (NO₃⁻) that is converted to nitric oxide through the nitrate-nitrite-NO pathway — a completely separate and complementary pathway to the arginine-eNOS route used by citrulline and Nitrosigine. This dual-pathway NO production makes beetroot a unique and evidence-backed endurance and pump ingredient.

Omega-3 fatty acids EPA and DHA are essential polyunsaturated fats critical for cardiovascular health, brain structure, inflammation resolution, and cellular membrane fluidity. They are the most researched supplement category globally.

Curcumin is the principal curcuminoid of turmeric (Curcuma longa), with potent anti-inflammatory and antioxidant properties rivaling pharmaceutical agents in some clinical comparisons. Its major limitation — poor native bioavailability — is overcome by enhanced formulations.

Urolithin A is a postbiotic metabolite naturally produced when gut bacteria metabolize ellagitannins from pomegranate and berries. Direct supplementation bypasses gut microbiome variability, ensuring consistent delivery of this potent mitophagy activator.

Piperine is the primary pungent alkaloid found in black pepper (Piper nigrum) and long pepper (Piper longum). It is the most widely studied and utilized natural bioenhancer, dramatically increasing the absorption and bioavailability of a vast range of co-administered nutrients, vitamins, and supplement ingredients through multiple complementary mechanisms.